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Author: Admin | 2025-04-28
A type of drug called a neprilysin inhibitor. An example is the heart failure drug sacubitril/valsartan (Entresto).Taking Zestril with a neprilysin inhibitor can increase your risk of angioedema.Before you start treatment with Zestril, it’s important to tell your doctor if you take a neprilysin inhibitor. They’ll likely have you stop taking the neprilysin inhibitor and wait at least 36 hours before starting treatment with Zestril. Likewise, after you stop taking Zestril, your doctor will typically have you wait at least 36 hours before starting treatment with a neprilysin inhibitor.Having diabetes and taking aliskirenIf you have diabetes, doctors typically will not prescribe Zestril in combination with a drug called aliskiren (Tekturna).This is because people with diabetes have a higher risk of kidney problems, low blood pressure, and high potassium levels if they take Zestril with aliskiren. When potassium levels in your blood are too high, there’s an increased risk of certain heart problems, including arrhythmias (irregular heart rhythms) and heart attacks. (Zestril is prescribed for high blood pressure and certain heart conditions.)If you have diabetes and take aliskiren, talk with your doctor before taking Zestril. They’ll likely prescribe a treatment other than Zestril for your condition. Or they may have you stop taking aliskiren before starting treatment with Zestril.Are pregnant or may become pregnantDoctors typically will not prescribe Zestril if you’re pregnant. They’re also unlikely to prescribe the drug if you’re able to become pregnant and are not using effective birth control.This is because Zestril may not be safe to take during pregnancy. In fact, the drug has a boxed warning about the risk of fetal harm. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). For details, see the “Boxed warning” note at the beginning of this article.Your doctor can recommend a different treatment for high blood pressure or a heart condition that’s safe for use in pregnancy. If you’re able to become pregnant, your doctor can advise you on birth control options to use while taking Zestril.Having had an allergic reaction to Zestril or any of its ingredientsYour doctor will likely not prescribe
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