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Author: Admin | 2025-04-28
How They Work How do phosphodiesterase-5 enzyme inhibitors work? Uses How are phosphodiesterase-5 enzyme inhibitors used? Side Effects What are side effects of phosphodiesterase-5 enzyme inhibitors? Drug Names What are names of phosphodiesterase-5 enzyme inhibitor drugs? How do phosphodiesterase-5 enzyme inhibitors work?Phosphodiesterase-5 enzyme inhibitors are medications used to treat erectile dysfunction, enlarged prostate (benign prostate hyperplasia), and pulmonary arterial hypertension (PAH), a condition of high blood pressure in the arteries that carry deoxygenated blood from the heart to the lungs.Phosphodiesterase-5 enzyme inhibitors work in the following ways: Relax the smooth muscles in the penis and increase blood flow into the corpus cavernosum, the erectile tissue in the penis. Improve blood flow in the prostate and relieve urinary symptoms associated with an enlarged prostate. Relax the smooth muscles around the pulmonary arteries, which results in arterial dilation and reduced pulmonary blood pressure. Normally, sexual stimulation causes nitrous oxide to be released into the corpus cavernosum, which increases the concentration of a signaling molecule known as cyclic guanosine monophosphate (cGMP). An increase in cGMP levels leads to relaxation of vascular smooth muscles, dilation of blood vessels, and improved blood flow.The phosphodiesterase-5 enzyme regulates cGMP levels by degrading them. Phosphodiesterase-5 enzyme inhibitors prevent PDE-5 from degrading cGMP, increase its concentration in the tissue, and enhance the muscle relaxation effects of nitrous oxide.How are phosphodiesterase-5 enzyme inhibitors used?Phosphodiesterase-5 enzyme inhibitors are administered orally as tablets or suspensions, or as intravenous injections for the treatment of the following conditions:FDA-approved: Erectile dysfunction Benign prostatic hyperplasia with or without erectile dysfunction Pulmonary arterial hypertension, to improve exercise ability and slow down the progression of disease in patients with: Idiopathic PAH Inherited PAH PAH caused by connective tissue diseases Orphan designation: Duchenne muscular dystrophy (an inherited muscle degeneration disorder) What are names of phosphodiesterase-5 enzyme inhibitor drugs?Generic and brand names of phosphoesterase-5 enzyme inhibitor drugs include: Adcirca Alyq avanafil Cialis Levitra Revatio sildenafil Staxyn ODT Stendra tadalafil vardenafil Viagra From References https://reference.medscape.com/drugs/phosphodiesterase-5-enzyme-inhibitors
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