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Author: Admin | 2025-04-28
To be seen, even with a loading dose. The effects of amiodarone may continue to increase for several weeks until a plateau is reached. The relationship between the concentration of amiodarone and its effects is not well established, although generally 1 to 2.5 mg/L is suggested as the ideal range for amiodarone blood levels. Levels below this range are more likely to be associated with ineffectiveness, and levels above this range are likely to be associated with toxicity and increased side effects. Amiodarone has a very long half-life (this is the time it takes for 50% of a dose of amiodarone to be eliminated by the body) of 15 to 142 days. It also has an active metabolite, desethylamiodarone that has a half-life of 75 days. Potentially it may take weeks to months for amiodarone to be totally cleared from the body. This means side effects and interactions may persist even on amiodarone discontinuation. 7. Interactions Medicines that interact with amiodarone may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with amiodarone. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with amiodarone include: alpha-blockers, such as prazosinanticonvulsants, such as carbamazepine, phenytoin, or phenobarbitalantidepressants, such as nefazodoneantifungal agents, such as itraconazole and ketoconazoleantipsychotic agents, such as cyclophosphamide, thioridazine, or clozapineaprepitantbarbituratesbeta-blockers, such as atenolol, labetalol, or metoprololbupropionchloroquineclopidogrelcyclosporindabigatrandigoxindofetilidedoxepinduloxetineHIV medications, such as atazanavir, darunavir, or ritonavirlevodopalidocaineloratadinelovastatinmedications that prolong the QT interval such as azithromycin, clarithromycin, or pimozidemedications that slow the heart rate, such as calcium channel blockersmifepristoneother medications that inhibit or induce CYP2D6, CYP2C8, or CYP3A4, such as fluoxetine, duloxetine, clarithromycin, erythromycin,
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