Comment
Author: Admin | 2025-04-28
Effects of CNS depressants. [6892] Grapefruit juice: (Major) Patients receiving buspirone should be advised to avoid drinking large amounts of grapefruit juice. In a study in healthy volunteers, coadministration of buspirone (10 mg single dose) with grapefruit juice (200 mL double-strength three times daily for 2 days) increased plasma buspirone concentrations significantly (4.3-fold increase in Cmax; 9.2-fold increase in AUC). Subjective drowsiness and other side effects of buspirone, like dizziness, nausea, headache, nervousness, or restlessness. may be increased with grapefruit juice ingestion. [28501] [29863] Haloperidol: (Moderate) Monitor for adverse effects, such as excess sedation and QT prolongation, during coadministration of buspirone and haloperidol. Mild to moderate increases in haloperidol plasma concentrations have been reported during concurrent use of haloperidol and buspirone. Elevated haloperidol concentrations may increase the risk of adverse effects, including QT prolongation. [28307] [28501] Homatropine; HYDROcodone: (Moderate) Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. [30379] HYDROcodone: (Moderate) Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. [30379] HYDROcodone; Ibuprofen: (Moderate) Concomitant use of hydrocodone with other central nervous system depressants, such as buspirone, can potentiate the effects of hydrocodone and may lead to additive CNS or respiratory depression. If hydrocodone is used with buspirone, the dose of one or both drugs should be reduced. [30379] HYDROmorphone: (Moderate) Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of hydromorphone, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. [28501] Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate: (Major) Avoid concomitant use of buspirone and reversible monoamine oxidase inhibitors (MAOIs), such as methylene blue, due to the risk for serotonin syndrome. For patients who are chronically receiving buspirone therapy and require emergency treatment with intravenous (IV) methylene blue, use the lowest possible IV methylene blue dose and hold buspirone until 24 hours after the last dose of IV methylene blue. The risk for serotonin syndrome is greatest with IV methylene blue doses of 1 mg/kg or more. Monitor for serotonin syndrome for 2 weeks or until 24 hours after the last dose of IV methylene blue, whichever comes first. Starting buspirone in a patient who is being treated with IV methylene blue is contraindicated. [28501] [60731] Ibuprofen; oxyCODONE: (Moderate) Concomitant use of CNS depressants, such as buspirone, can potentiate the effects of oxycodone, which may potentially lead to respiratory depression, CNS depression, sedation, or hypotensive responses. If concurrent use of codeine and buspirone is imperative, reduce the dose of one or both drugs. [28501]
Add Comment