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Author: Admin | 2025-04-28
Gabapentin in the treatment of alcohol withdrawal Ahmed 2019.Based on the VA/DoD clinical practice guideline for the management of substance use disorders, gabapentin given for mild alcohol withdrawal is suggested as an alternative agent when the risk of benzodiazepines outweigh the benefits (eg, inadequate monitoring available, abuse liability, contraindication, adverse reaction) VA/DoD 2015.Cough, chronic refractory (alternative agent)cyesData from a small, randomized, double-blind, placebo-controlled trial showed that gabapentin significantly improves cough-specific quality of life in patients with refractory chronic cough compared to placebo. Participants with central sensitization of the cough reflex exhibited a greater response to gabapentin treatment compared to participants without central sensitization Ryan 2012.Based on the American College of Chest Physicians (ACCP) guidelines for the treatment of unexplained chronic cough, gabapentin, on a therapeutic trial basis, is suggested in patients with unexplained chronic cough as long as the potential side effects and risk-benefit profile are discussed prior to use, and there is reassessment at 6 months prior to continuation of treatment ACCP [Gibson 2016].Fibromyalgia (alternative agent)bData from a randomized, double-blind, placebo-controlled study support the use of gabapentin in the treatment of pain and sleep disturbances associated with fibromyalgia Hiccups (singultus)cData from a limited number of patients in case reports/series and a retrospective chart review suggest that gabapentin (monotherapy or as an adjunct to other agents such as baclofen, cisapride, omeprazole, haloperidol, and metoclopramide) may decrease the frequency and severity of persistent or intractable hiccups Neuropathic pain (other than postherpetic neuralgia)ayesIn a meta-analysis of trials evaluating the treatment of neuropathic
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