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Author: Admin | 2025-04-28
There are multiple interactions reported between these two agents. Interaction Details Losartan Potassium is classified as belonging to the following category: Antihypertensive Drugs Theoretically, berberine might have additive effects with antihypertensive drugs.Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. Interaction Rating Moderate Likelihood of Occurrence Possible Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists References Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132. Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. Interaction Details Losartan Potassium is classified as belonging to the following category: Cytochrome P450 2C9 (Cyp2C9) Substrates Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, taking berberine with drugs metabolized by CYP2C9 might increase drug levels and increase the risk of adverse effects. Interaction Rating Moderate Likelihood of Occurrence Possible Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists References Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. Interaction Details Losartan Potassium is classified as belonging to the following category: Cytochrome P450 3A4 (Cyp3A4) Substrates Theoretically, berberine might increase serum levels of drugs metabolized by CYP3A4.In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, use of berberine with drugs metabolized by CYP3A4 might increase drug levels and increase the risk of
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