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Author: Admin | 2025-04-28
There are a variety of Nyquil products currently available over-the-counter, but most contain the following active ingredients:AcetaminophenDextromethorphanDoxylamineAcetaminophen is for pain management, dextromethorphan is for cough suppression, and doxylamine is an antihistamine used for sleep, runny nose, sneezing, itching, and watery eyes.Doxylamine is the ingredient in NyQuil that causes sedation as it is a first-generation antihistamine (similar to Benadryl).Melatonin is naturally produced in our bodies to help regulate the sleep-wake cycle but is also a commonly used over-the-counter supplement to help treat insomnia.Online interaction checkers will often list NyQuil products and melatonin as having an interaction with one another due to their additive effects.This is because both doxylamine and melatonin produce sedation and have mild CNS (central nervous system) depressant properties. Due to this, it is recommended to use these products together with caution.Use together will cause additive sedation, but that's generally the extent of the interaction.Interaction DetailsThere haven't been any studies that have specifically evaluated the risk of using NyQuil and melatonin together, but based on their known effects, taking both could potentially lead to additive sedation, sleep-related disturbances, CNS, and respiratory depression.If taking these two together, it is important to report any unusual sleep-related behaviors and one of the products may need to be discontinued.There may be situations where both are recommended, like if you are using melatonin to help treat 'jet lag' (i.e. trying to get your sleep-wake cycle back on your normal schedule) but you should talk to your doctor first before combining.How Antihistamines WorkAntihistamines bind to histamine receptors that are found in the nose, lungs, eyes, and skin without activating the histamine response. By binding and changing the shape of the histamine receptor, antihistamines inhibit histamine from binding and creating its response.First-generation antihistamines, like doxylamine, are not selective for any particular tissue and are therefore more
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