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Author: Admin | 2025-04-28
Hemolysis, pancytopenia, granulocytopeniaPostmarketing reports: Thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura[Ref]Severe cases of thrombocytopenia that were fatal or life-threatening have been reported. Thrombocytopenia generally resolved within a week when this drug was discontinued.Hemolysis has been reported in certain susceptible glucose-6-phosphate deficient patients.[Ref]HepaticFrequency not reported: Hepatitis, cholestatic jaundice, hepatic necrosis, elevated serum transaminase, elevated bilirubin, hepatic changes, abnormal elevations in serum transaminase levels, jaundice, elevated liver enzymes, disturbance in liver enzymes[Ref]Cases of cholestatic jaundice and hepatic necrosis have been fatal.Jaundice (generally mild and transient) has been reported rarely, often occurring in patients with history of infectious hepatitis.[Ref]HypersensitivityFrequency not reported: Hypersensitivity, allergic skin reactions, anaphylaxis, serum sickness-like syndrome, generalized allergic reactions, anaphylactic/anaphylactoid reactions, severe hypersensitivity reactions (including associated with P jirovecii pneumonia), serum sickness[Ref]LocalFrequency not reported: Local reaction, pain, slight/local irritation, inflammation[Ref]Local reaction, pain, and slight irritation were reported infrequently with IV administration.[Ref]MusculoskeletalFrequency not reported: Arthralgia, myalgia, rhabdomyolysis, systemic lupus erythematosus, muscle weakness[Ref]Rhabdomyolysis has been reported with this drug, primarily in patients with AIDS.[Ref]OcularFrequency not reported: Uveitis, conjunctival and scleral injection/redness/edema, periorbital edema, corneal ring infiltrates, vision problems[Ref]PsychiatricFrequency not reported: Depression/mental depression, hallucinations, apathy, nervousness, insomnia, psychotic disorder, confusional state, agitation, anxiety, abnormal behavior, nightmares[Ref]RenalFrequency not reported: Renal impairment/failure, interstitial nephritis, tubulointerstitial nephritis and uveitis syndrome, elevated BUN, elevated serum creatinine, toxic nephrosis, renal tubular acidosis, nephrotoxicity, functional kidney changes, abnormal elevations in serum urea, abnormal elevations in serum creatinine, stone formation, tubular necrosis, aggravation of renal disease, azotemia, hyperkalemic renal tubular acidosis, overestimations of normal creatinine values[Ref]Nephrotoxicity has been reported in association with cyclosporine.[Ref]GenitourinaryFrequency not reported: Oliguria, anuria, crystalluria, diuresis, dysuria, hematuria, urgency changes, abnormal elevations in urine protein levels[Ref]Diuresis has been reported in patients using sulfonamides.[Ref]RespiratoryFrequency not reported: Cough, dyspnea/shortness of breath, pulmonary infiltrates/lung infiltration, epistaxis, eosinophilic/allergic alveolitis, wheezing[Ref]Cough, dyspnea, and lung infiltration have been early indicators of respiratory hypersensitivity which, while very rare, has been fatal.[Ref]References1. (2022) "Product Information. Septra (sulfamethoxazole-trimethoprim)." Glaxo Wellcome2. (2004) "Product Information. Sulfamethoxazole-Trimethoprim (sulfamethoxazole-trimethoprim)." Teva SICOR Pharmaceuticals Inc3. Cerner Multum, Inc. "UK Summary of Product Characteristics."4. Cerner Multum, Inc. "Australian Product Information."Frequently asked questionsWhat drugs should be avoided with a sulfa allergy?Does Bactrim cause headaches?Does Bactrim make you tired?How long does it take for a boil to heal while taking Bactrim?Can I drink alcohol when taking sulfamethoxazole / trimethoprim DS?What dose of co-trimoxazole is used in a patient with a UTI?Further informationBactrim side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.Medical Disclaimer
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