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Author: Admin | 2025-04-28
They do use living cells or creatures, that’s in vivo.)This revealed that nuciferine’s most potent target was the D2 dopamine receptor – it was characterized as a partial agonist.The other two most potent activities were found in inhibiting 5-HT1D (serotonin) and alpha-01D (adrenergic) receptors…These make it an anti-serotonergic as well as a vaso-relaxant agent.“Functional studies indicate that nuciferine shows appreciable potency as a D2 partial agonist… Nuciferine was a partial agonist at D2 receptors with an activity…similar to aripiprazole…” (Farrell, 2016)(Aripiprazole is an antipsychotic medicine.)When used in normal amounts, nuciferine would seem to behave as a D2activator – similar to apomorphine and bromocriptine.This is especially relevant considering that the D2 receptor is responsible for releasing oxytocin…This effect has been reliably demonstrated in rats (Clarke, 1979), monkeys (Amico, 1993), and humans (Nussey, 1988).In fact, this D2-oxytocin mechanism had been proven to underlie apomorphine’s success in treating ED (Melis, 1988).So now we have a realistic explanation for the traditional use of blue lotus, giving us confidence towards the idea that it works.After all, two other D2-dopaminergic agents, bromocriptine and apomorphine, have been proven quite successful for enhancing the erectile response.Although nuciferine isn’t quite as potent as apomorphine in vitro, there are a few reasons to suppose it could be just as powerful upon ingestion.This is because nuciferine has an open‑ring isomer called atherospermine, a form of the molecule that even better resembles dopamine.The open ring isomer of nornuciferine, also found in blue lotus, resembles dopamine even more:Apomorphine also has an open‑ring isomer.But,
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