Cell cycle specific chemotherapy drugs

drugs. G1. S. G2. M. Chemotherapy drug classification. Cell cycle phase specific (CCPS) drugs. Current chemotherapy regimens tend to combine CCPS and CCPNS

Cell cycle phase non-specific (CCPNS) drugs. Chemotherapy drug mechanisms are generally divided into two categories: Order of administration. Act as specific

Chemotherapy drugs that kill cancer cells when they are at rest are called cell-cycle non-specific. On the other hand, chemotherapy drugs that kill cancer cells only when they are dividing are called cell-cycle specific. Some drugs specifically attack cells in a particular phase of the cell cycle (the M or S phases, for example).

Cytotoxic chemotherapy mechanisms of action may be cell cycle- dependentarresting cancer cell growth at specific phases in the Some drugs damage cells

CELL CYCLE PHASE-SPECIFIC CHEMOTHERAPY 370 Cell Cycle 2024; Vol. 1 Issue 6 Table 1 MODELS DIRECTED TO CELL CYCLE PHASE-SPECIFIC CHEMOTHERAPY Model Focus Simple Models Single drugs and single issues: safety, efficacy, resistance evolution. Dose response Fundamental difference between cell-cycle specific and cell-cycle nonspecific drugs.

Cell cycle phase non-specific (CCPNS) drugs. Chemotherapy drug mechanisms are generally divided into two categories: Order of administration. Act as specific

Cell cycle phase non-specific (CCPNS) drugs. Chemotherapy drug mechanisms are generally divided into two categories: Order of administration. Act as specific

drugs. G1. S. G2. M. Chemotherapy drug classification. Cell cycle phase specific (CCPS) drugs. Current chemotherapy regimens tend to combine CCPS and CCPNS

Cell-cycle specific chemotherapy drugs only affect cells when they are dividing, whereas cell-cycle non-specific drugs affect cells when they are at rest. [13] Lomustine is a cell cycle non-specific, highly lipophilic alkylating agent which produces chloroethyl carbenium ions and carbamylating intermediates in vivo.