Bupropion and mdma

☑️@bupropion_and_mdma · 8837 subscribers · Content 18+ 🔞
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Actual: Bupropion - may test false positive for MDMA (3,4-methylenedioxymethamphetamine). Bupropion - may test false positive for amphetamine and MDMA. Buproprion
4.8 rating 2025-04-25
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Bupropion (Wellbutrin, Zyban) - false positive for Amphetamines. Bupropion - may test false positive for MDMA (3,4-methylenedioxymethamphetamine). Bupropion

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How does bupropion interact with MDMA? In the brain, MDMA acts as a stimulant that is capable of releasing serotonin, norepinephrine, and dopamine via carrier

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Bupropion MDMA. Schmid et al. (2025) studied the combination of bupropion XR (titrated to 300 mg p.o. over 7 days) with MDMA (125 mg p.o. administered concurrently with bupropion XR 300 mg on day 7). The researchers hypothesized that DAT and NET blockade by bupropion pretreatment would attenuate the mood and cardiostimulant effects of MDMA.

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Caution in combination. Consider taper. discontinuation of bupropion. Alternatively, a 25% reduced dose of MDMA if bupropion is continued.

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Bupropion MDMA. Schmid et al. (2024) studied the combination of bupropion XR (titrated to 300 mg p.o. over 7 days) with MDMA (125 mg p.o. administered concurrently with bupropion XR 300 mg on day 7). The researchers hypothesized that DAT and NET blockade by bupropion pretreatment would attenuate the mood and cardiostimulant effects of MDMA.

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Caution in combination. Consider taper. discontinuation of bupropion. Alternatively, a 25% reduced dose of MDMA if bupropion is continued.

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Bupropion and MDMA, Risky Combination? Risks of Combining Bupropion with MDMA. Combining bupropion with MDMA elevates the blood concentration of both drugs.

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Bupropion did affect self-reported subjective complaints from MDMA, although bupropion significantly prolonged the positive mood effects of MDMA. There was an increase in MDMA levels and reduction in the primary metabolites, DHMA and HMMA, suggesting inhibition of CYP2D6 by bupropion ( Steuer et al. 2024 ).

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Bupropion MDMA. Schmid et al. (2024) studied the combination of bupropion XR (titrated to 300 mg p.o. over 7 days) with MDMA (125 mg p.o. administered concurrently with bupropion XR 300 mg on day 7). The researchers hypothesized that DAT and NET blockade by bupropion pretreatment would attenuate the mood and cardiostimulant effects of MDMA.

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