Bleomycin pulmonary toxicity
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The cytotoxic agent bleomycin is feared for its induction of sometimes fatal pulmonary toxicity, also known as bleomycin-induced pneumonitis (BIP). The central event in the development of BIP is endothelial damage of the lung vasculature due to bleomycin-induced cytokines and free radicals.
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Imatinib Treatment for Bleomycin-Induced Pulmonary Toxicity The basic treatment for bleomycin-induced pulmonary toxicity is corticosteroids.
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Bleomycin pulmonary toxicity is a direct consequence of free radical damage caused by bleomycin, iron, and oxygen forming a complex that cleaves cellular deoxyribonucleic acid (DNA). The lungs are at a higher risk of bleomycin-free radical damage because they lack the enzyme bleomycin hydrolase, which inactivates bleomycin.
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Monitor for pulmonary toxicity when bleomycin is used with nephrotoxic drugs (may reduce bleomycin clearance) or with other drugs that may cause pulmonary
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by WG Martin 2024 Cited by 354Bleomycin-containing chemotherapy is not without toxicity. Bleomycin pulmonary toxicity (BPT) has been well described in HL patients treated
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Pulmonary toxicities occur in 10% of treated patients. In approximately 1%, the nonspecific pneumonitis induced by bleomycin progresses to pulmonary fibrosis
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Bleomycin is really the primary chemotherapy related to toxicity in Hodgkin lymphoma. The ABVD regimen has pulmonary toxicity, which can be
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Pulmonary toxicities occur in 10% of treated patients; in approximately 1%, the nonspecific pneumonitis induced by bleomycin progresses to pulmonary fibrosis and death; although this is age and dose-related, the toxicity is unpredictable; frequent roentgenograms recommended
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Bleomycin stands out for its high incidence of pulmonary toxicity, affecting up to 10% of patients undergoing treatment. Amiodarone, known for
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