Mao drugs

☑️@mao_drugs · 1446 subscribers · Content 18+ 🔞
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Actual: MECHANISM OF DRUG INTERACTION. MAO exists as 2 isoforms, MAO-A and MAO-B. Inhibition of MAO-A reduces the metabolism of both serotonin and noradrenaline, whereas inhibition of MAO-B does not affect the metabolism of these neurotransmitters, unless sufficient doses (as described below) are used. 15 Inhibition of MAO-B, the major isoform in the
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@can_you_take_ib

Newer MAO inhibitor drugs, including selegiline (Eldepryl) and rasagiline (Azilect), target MAO-B and are called selective MAO inhibitors. Selegiline is

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The efficacy of the inhibitor binding into the unique substrate binding sites of MAO-A and MAO-B ultimately determines a drug s relative selectivity at inhibiting MAO-A, MAO-B, or both. The substrate binding sites of both MAO-A and MAO-B are mainly hydrophobic except for a conserved lysine that interacts with a water molecule.

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Newer MAO inhibitor drugs, including selegiline (Eldepryl) and rasagiline (Azilect), target MAO-B and are called selective MAO inhibitors. Selegiline is

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The human brain contains more MAO-B than MAO Their dependence on hepatic metabolism predisposes MAO inhibitors to potential drug interactions with other drugs

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Newer MAO inhibitor drugs, including selegiline (Eldepryl) and rasagiline (Azilect), target MAO-B and are called selective MAO inhibitors. Selegiline is

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A drug that prevents the activity of the enzyme monoamine oxidase (MAO). MAO inhibitors include phenelzine, isocarboxazid, and tranylcypromine. These drugs

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The efficacy of the inhibitor binding into the unique substrate binding sites of MAO-A and MAO-B ultimately determines a drug s relative selectivity at inhibiting MAO-A, MAO-B, or both. The substrate binding sites of both MAO-A and MAO-B are mainly hydrophobic except for a conserved lysine that interacts with a water molecule.

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The monoamine oxidase (MAO) enzymes include MAO-A and MAO-B. The catecholamines are metabolized by both MAO-A and MAO-B, whereas 5-HT is metabolized only by MAO-A. The four irreversible MAOIs marketed in the United States include the nonselective MAOIs phenelzine and tranylcypromine and the MAO-B selective drugs selegiline and isocarboxazid ((2)).

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Examples of Drugs 1.Non-selective MAO inhibitors Inhibit both MAO-A and MAO-B. Phenelzine (Nardil) Isocarboxazid (Marplan) Tranylcypromine

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