Bone resorption inhibitors

Miscellaneous bone resorption inhibitors are drugs that inhibit mineralization or resorption of the bone. These agents work by different mechanisms to decrease bone resorption and prevent calcium loss from the bones.

All bisphosphonates inhibit bone resorption by attaching to hydroxyapatite binding sites on the bone, particularly in areas with active resorption. As osteoclasts resorb bone, the bisphosphonate embedded in the bone is released and impairs the osteoclast s ability to continue bone resorption.

There had therefore been an expectation that the responses to a cathepsin K inhibitor might be different from other anti-resorptive drugs, based on the notion that inhibition of cathepsin K may partially uncouple the link between reduction in bone resorption and bone formation, allowing bone formation to continue while bone resorption is

by S Zhou 2024 Cited by 48Currently, the main therapeutic drugs for osteoporosis are bone resorption inhibitors [[115], [116], [117]]. These drugs inhibit bone resorption

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All bisphosphonates inhibit bone resorption by attaching to hydroxyapatite binding sites on the bone, particularly in areas with active resorption. As osteoclasts resorb bone, the bisphosphonate embedded in the bone is released and impairs the osteoclast s ability to continue bone resorption.

Alendronate is a potent inhibitor of bone resorption and is most commonly used in the treatment and prevention of osteoporosis.

by H Tobe 2024 Cited by kinase (PI3-kinase) inhibitor, inhibited bone resorption.18.19). Humulone may inhibit bone resorption by its inhibitory activity on the signal transduction

Bone resorption inhibitors are drugs that inhibit mineralization or resorption of the bone by blocking the action of osteoclasts. They are used to treat postmenopausal and glucocorticoid induced osteoporosis, Paget's disease of the bone and malignant hypercalcemia.