Gabapentin for dystonia
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by S Onoe 2024Gabapentin-related dystonia is rare, occurring mainly at high doses. We herein report a rare case of dystonia induced by low-dose gabapentin.
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dystonia which often manifests as 'brittle /unstable dystonia' or status dystonicus (see section 2). Gabapentin is sometimes used and is currently being
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Gabapentin is a gabaergic agent and therefore it can be useful in dystonia. 28 patients with different forms of dystonia and hemifacial spasm were included in this open study. They received
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Levodopa can be considered as part of a diagnostic evaluation (with biochemical and genetic testing) if there is a suspicion that an individual may have dopa-responsive dystonia. Clonidine or gabapentin are suggested when dystonia is severe. With increasing dystonia severity, multiple medications may be required.
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dystonia. Baclofen and gabapentin used together relieved the inspiratory stridor and improved the generalized dystonia of two patients, confirming the
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by JP Lin 2024 Cited by 42Monogenic isolated dystonias, dystonia plus, and even pro- gressive Gabapentin can significantly improve dystonia severity and quality.
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Little is known about gabapentin in dystonia. What this paper adds Gabapentin can provide significant relief of childhood dystonia Gabapentin relieves dystonia-related pain, poor sleep, distress and lack of contentedness Gabapentin can improve activity and participation in children with severe dystonia not responding to con-ventional management.
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prior to a 600mg gabapentin capsule, mean gabapentin AUC increased by 44% compared to gabapentin administered without dystonia). Eye
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Gabapentin may significantly ameliorate dystonia severity and improve activities of daily living and quality of life in children with severe dystonia. Keywords Dystonia
Comments
This story is great fun; it's sexy too. I especially enjoyed the heroine/narrator's personality, including her fairly strong—but decidedly quirky—ethical principles. I do feel sorry for her uncle, though. He got left out of the action entirely. Perhaps there will be a Part 3? Fine with me, if so.
Not much good news. Went to my neuropathist on Wednesday for a series of tests. 'Yes', I have nerve damage and 'no', the doctor looking at the results couldn't understand why. Essentially, they ran an escalating electric current from various spots on my lower leg and foot to toes to see how I responded. I highly recommend this as a means of torture.
On the downside, I am becoming resistant to my pain medication, so life sucks coming and going. My psychiatrist upped my Gabapentin from 300 Mg to 400 Mg [3x a day] and it isn't helping. Woot? I'd kill for a decent night's sleep.
Thank you for asking. I really wish I had better news.
James aka FinalStand
On the beneficial side, I know where I want to take Chapter 5 in this tale. I have much of it mapped out in my mind.
They travel to the mainland in pursuit of the Atlanteans ... which completes the 13th Circle of the Black Witches Coven (whoops!) ~ giving the descendants of the other 7 the power they have been long denied. There is still the government task force on the serial killings to deal with plus the on-going conflict with the White Coven. The main mystery remains ~ what was an Atlantean doing breeding with an Abenaki and teaching at least one half-breed offspring magic over 400 years ago ... and why would a normally amoral Altantean 'noble' be interested in said half-breed today?
God - sometimes I really wish I had a clone ... or two.
James aka FinalStand
As for everyone else ... life keeps adding on the 'happy' {sarcasm}.
My neurologist decided to prescribe a more powerful tool to manage the pain in my feet. So, he gave me a foot cream. What wasn't obvious was the non-prescribed 'side effects' of the foot cream which included ... (sigh) ...
Well, as my feet have been hurting like sons-a-bitches, I was slathering that cream on three and four times a day. It had minimal positive effect which was leagues ahead of the pain I was going through. Besides, it was foot cream. What was the worse that could happen?
Baclofen (2%) ~ [Lightheadedness or fainting, trouble seeing, severe tiredness, weakness],
Cyclobenzaprine (2%) ~ [Anxiety, restlessness, seeing or hearing things that are not there, severe drowsiness, fainting, or confusion],
Diclofenac (3%) ~ [Sudden or severe headache, or problems with vision, speech, or walking],
Gabapentin (6%) ~ [Behavior problems, aggression, restlessness, trouble concentrating, moodiness (especially in children), problems with coordination, shakiness, unsteadiness, unusual moods, or behaviors, thoughts of hurting yourself, feeling depressed, dizziness, drowsiness, sleepiness, tiredness],
Lidocaine (2%) ~ [which, somewhat stunningly, isn't trying to fuck with my head]
So I've been staggering around in a semi-lucid state for the past several days, unable to figure out why I couldn't do much, if any, writing. It took me complaining to my wife to provide some clarity.
I repeat - it is freaking foot cream!
I've stopped with the foot-crack and am back to dealing with the pain. Hopefully I'll be back to writing soon too.
James aka FinalStand