Are platinum drugs renally cleared

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Actual: The renal clearance of free platinum is nonlinear and variable and is dependent on dose, urine flow rate, and individual variability in the
4.7 rating 2025-04-24
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European officials cleared the drug for use in combination with certain platinum-based chemotherapy. At a median follow-up of 17.3 months, the

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When renally cleared drugs are administered to patients with reduced renal function, drug accumulation leading to supratherapeutic

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Intact cisplatin accounts for the majority of platinum excreted in the urine within one hour of administration. Renally excreted drugs. Literature data

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platinum and 5FU or the FLOT regimen are all options . Targeted renal replacement therapy needs. While the progression of CKD

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renal impairment or who develop significant reductions in creatinine clearance during treatment It is a chemotherapy drug that contains platinum. It is

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Usually, a platinum drug (cisplatin or carboplatin) is combined The treatment of advanced non-clear cell renal carcinoma. UpToDate

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by WH Li 2024 Cited by 6The present study also shows that platinum is the main chemotherapy drug that causes renal impairment in elderly patients with malignant tumors.

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Platinum analogues Tyrosine kinase inhibitors Vinca alkaloids Cardiovascular Diabetic drugs Pituitary hormones Renal preparations Sex hormones

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Patients with known severe hypersensitivity to platinum containing compounds Anticancer drug renal toxicity and elimination: dosing guidelines for altered.

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