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Tadalafil has been on the market for 20 years as Eli Lilly’s erectile dysfunction drug Cialis, and is now subject to generic competition. Opsumit was approved in 2025 for PAH.

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Eli Lilly and Company; Lilly Corporate Center; Indianapolis, IN ; Safety and efficacy not established Erectile Dysfunction Adjust tadalafil dose for PAH; if on cobicistat, start tadalafil 20 mg/day and may increase up to 40 mg/day; avoid

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Tadalafil is an orally active, selective, small molecule developed by Eli Lilly for the treatment of erectile dysfunction, benign prostatic hyperplasia, Tadalafil - Eli Lilly and Company Tadalafil - Eli Lilly and Company Alternative Names: Adcirca; Cialis; GF- ; IC-351; LY ; Zalutia

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